This is the fifth edition of a comprehensive medical textbook on diabetes mellitus, edited by Richard I.G. Holt, Clive S. Cockram, Allan Flyvbjerg, and Barry J. Goldstein. It is intended for healthcare professionals, researchers, and students in endocrinology and related fields. The book covers the full spectrum of diabetes, from its history and classification to pathogenesis, treatment,…
This is the fifth edition of the Textbook of Diabetes, a comprehensive medical reference edited by Richard I.G. Holt, Clive S. Cockram, Allan Flyvbjerg, and Barry J. Goldstein. It is intended for healthcare professionals, researchers, and students in endocrinology and related fields. The book covers the full spectrum of diabetes, from its history and classification to pathogenesis, treatment, complications, and future directions.
Part 1 places diabetes in its historical and social context, covering the history of diabetes mellitus, classification and diagnosis, and the epidemiology of both type 1 and type 2 diabetes. It also addresses the global burden of diabetes. Part 2 covers normal physiology, including islet function, insulin secretion, glucagon regulation, the mechanism of insulin action, and weight control.
Part 3 examines the pathogenesis of diabetes, including autoimmune type 1 diabetes, insulin secretion defects and beta-cell dysfunction in type 2 diabetes, insulin resistance, genetic architecture, metabolic disturbances, obesity, and the microbiome. Part 4 covers other types of diabetes such as monogenic causes, drug-induced diabetes, endocrine disorders, and pancreatic diseases.
Part 5 focuses on managing the patient with diabetes, including clinical presentations, aims of care, education, lifestyle issues (diet and exercise), monitoring, and drug therapy considerations. Part 6 details treatment approaches, including insulin therapy, new technologies for glucose monitoring and insulin administration, oral glucose-lowering agents, non-insulin parenteral therapies, combination therapies, in-hospital treatment, hypoglycemia, and acute metabolic complications.
Parts 7 and 8 cover microvascular and macrovascular complications, including pathogenesis, diabetic retinopathy, nephropathy, neuropathy, cardiovascular risk factors, dyslipidemia, ischemic heart disease, congestive heart failure, cerebrovascular disease, and peripheral vascular disease. Part 9 addresses other complications such as foot problems, sexual function, gastrointestinal manifestations, non-alcoholic fatty liver disease, skin disorders, bone and rheumatic disorders, cancer risk, and…
Part 10 covers psychosocial aspects including psychological factors, psychiatric disorders, and social aspects. Part 11 addresses diabetes in special groups: childhood, adolescence and transition, pregnancy, old age, and end of life. Part 12 discusses delivery and organization of diabetes care, including the multidisciplinary team and models of care across different resource settings. Part 13 explores future directions including drug treatments, stem cell therapy, islet transplantation, gene…