CASE FILE: AMINOPHYLLINE CASE FILE: AMINOPHYLLINE“A Bronchodilator Drug Study”CASE NO. OO1 MEDICATION PROFILE DRUG STUDY ABELLO, FRITZIE GALE D. 3D1 CASE NO. OO1 MEDICATION PROFILE DRUG STUDY ABELLO, FRITZIE GALE D. 3D1
Date : PHARMACEUTICAL PROFILEPHARMACEUTICAL PROFILEDRUG IDENTITYDRUG IDENTITYDRUG IDENTITYDRUG IDENTITYCASE FILE 01: DRUG PROFILEGeneric Name: AminophyllineGeneric Name: AminophyllineGeneric Name: Aminophylline Brand Name:Brand Name:Brand Name: TruphyllineTruphyllineTruphylline PhyllocontinPhyllocontinPhyllocontin Aminophylline InjectionAminophylline InjectionAminophylline Injection NorphylNorphylNorphyl Drug Classification:Drug Classification:Drug Classification: Methylxanthine derivativeMethylxanthine derivativeMethylxanthine derivative Therapeutic Class:Therapeutic Class:Therapeutic Class: BronchodilatorBronchodilatorBronchodilator Generic Name: Aminophylline Brand Name: Truphylline Phyllocontin Aminophylline Injection Norphyl Drug Classification: Methylxanthine derivative Therapeutic Class: Bronchodilator Dosage/ Frequency/ Route of Administration: 5–6 mg/kg IV loading dose → continuous IV infusion; individualized dosing; FREQUENCY: Once, then continuous infusion ROUTE: IV (Intravenous) Dosage/ Frequency/ Route of Administration: 5–6 mg/kg IV loading dose → continuous IV infusion; individualized dosing; FREQUENCY: Once, then continuous infusion ROUTE: IV (Intravenous) Aminophylline is a bronchodilator that helpsAminophylline is a bronchodilator that helpsAminophylline is a bronchodilator that helps relax the airway muscles, improving airflowrelax the airway muscles, improving airflowrelax the airway muscles, improving airflow and breathing.and breathing.and breathing. Aminophylline is a bronchodilator that helps relax the airway muscles, improving airflow and breathing.
CASE FILE 02: Mechanism of ActionMechanism of ActionMechanism of Action Aminophylline releases theophylline, which producesAminophylline releases theophylline, which producesAminophylline releases theophylline, which produces bronchodilation by inhibiting phosphodiesterasebronchodilation by inhibiting phosphodiesterasebronchodilation by inhibiting phosphodiesterase enzymes and antagonizing adenosine receptors. Thisenzymes and antagonizing adenosine receptors. Thisenzymes and antagonizing adenosine receptors. This increases intracellular cAMP, causing relaxation ofincreases intracellular cAMP, causing relaxation ofincreases intracellular cAMP, causing relaxation of bronchial smooth muscles and improving airflow.bronchial smooth muscles and improving airflow.bronchial smooth muscles and improving airflow. IndicationIndicationIndication Aminophylline is used as an adjunct treatment forAminophylline is used as an adjunct treatment forAminophylline is used as an adjunct treatment for acute exacerbations with reversible airflowacute exacerbations with reversible airflowacute exacerbations with reversible airflow obstruction, particularly in asthma and otherobstruction, particularly in asthma and otherobstruction, particularly in asthma and other chronic respiratory conditions such as emphysema andchronic respiratory conditions such as emphysema andchronic respiratory conditions such as emphysema and chronic bronchitis.chronic bronchitis.chronic bronchitis. ContraindicationContraindicationContraindication Aminophylline is contraindicated in patients withAminophylline is contraindicated in patients withAminophylline is contraindicated in patients with hypersensitivity to theophylline, aminophylline, orhypersensitivity to theophylline, aminophylline, orhypersensitivity to theophylline, aminophylline, or ethylenediamine, a component of the drugethylenediamine, a component of the drugethylenediamine, a component of the drug formulation.formulation.formulation. Mechanism of Action Aminophylline releases theophylline, which produces bronchodilation by inhibiting phosphodiesterase enzymes and antagonizing adenosine receptors. This increases intracellular cAMP, causing relaxation of bronchial smooth muscles and improving airflow. Indication Aminophylline is used as an adjunct treatment for acute exacerbations with reversible airflow obstruction, particularly in asthma and other chronic respiratory conditions such as emphysema and chronic bronchitis. Contraindication Aminophylline is contraindicated in patients with hypersensitivity to theophylline, aminophylline, or ethylenediamine, a component of the drug formulation.
CASE 03:CASE 03: EFFECTS &EFFECTS & RISKSRISKS CASE 03: EFFECTS & RISKS Severe or persistent vomiting Tachycardia Cardiac arrhythmias Hypotension Seizures Cardiac arrest SIDE EFFECTSADVERSE EFFECTS AMINOPHYLLINE Nausea and vomiting Headache Restlessness Tremors Insomnia Abdominal discomfort Increased heart rate
111... Before AdministrationBefore AdministrationBefore Administration AAAssess respiratory status and breath sounds.ssess respiratory status and breath sounds.ssess respiratory status and breath sounds. Obtain baseline vital signs.Obtain baseline vital signs.Obtain baseline vital signs. Check history of seizures, cardiac arrhythmias,Check history of seizures, cardiac arrhythmias,Check history of seizures, cardiac arrhythmias, and liver disease.and liver disease.and liver disease. Review previous theophylline use.Review previous theophylline use.Review previous theophylline use. Check serum theophylline level when indicated.Check serum theophylline level when indicated.Check serum theophylline level when indicated. During AdministrationDuring AdministrationDuring Administration Administer exactly as prescribed.Administer exactly as prescribed.Administer exactly as prescribed. Give IV medication slowly or as a dilutedGive IV medication slowly or as a dilutedGive IV medication slowly or as a diluted infusion as ordered.infusion as ordered.infusion as ordered. Monitor heart rate, blood pressure, andMonitor heart rate, blood pressure, andMonitor heart rate, blood pressure, and respiratory status.respiratory status.respiratory status. Observe for signs of toxicity.Observe for signs of toxicity.Observe for signs of toxicity. 1.Before Administration Assess respiratory status and breath sounds. Obtain baseline vital signs. Check history of seizures, cardiac arrhythmias, and liver disease. Review previous theophylline use. Check serum theophylline level when indicated. During Administration Administer exactly as prescribed. Give IV medication slowly or as a diluted infusion as ordered. Monitor heart rate, blood pressure, and respiratory status. Observe for signs of toxicity. CASE FILE 04:
II. During AdministrationII. During AdministrationII. During Administration Administer exactly as prescribed.Administer exactly as prescribed.Administer exactly as prescribed. Give IV medication slowly or as a dilutedGive IV medication slowly or as a dilutedGive IV medication slowly or as a diluted infusion as ordered.infusion as ordered.infusion as ordered. Monitor heart rate, blood pressure, andMonitor heart rate, blood pressure, andMonitor heart rate, blood pressure, and respiratory status.respiratory status.respiratory status. Observe for signs of toxicity.Observe for signs of toxicity.Observe for signs of toxicity. III. After AdministrationIII. After AdministrationIII. After Administration Reassess respiratory status and response toReassess respiratory status and response toReassess respiratory status and response to treatment.treatment.treatment. Monitor for nausea, vomiting, tremors,Monitor for nausea, vomiting, tremors,Monitor for nausea, vomiting, tremors, palpitations, or seizures.palpitations, or seizures.palpitations, or seizures. Monitor serum theophylline levels as ordered.Monitor serum theophylline levels as ordered.Monitor serum theophylline levels as ordered. Document medication administration and patientDocument medication administration and patientDocument medication administration and patient response.response.response. II. During Administration Administer exactly as prescribed. Give IV medication slowly or as a diluted infusion as ordered. Monitor heart rate, blood pressure, and respiratory status. Observe for signs of toxicity. III. After Administration Reassess respiratory status and response to treatment. Monitor for nausea, vomiting, tremors, palpitations, or seizures. Monitor serum theophylline levels as ordered. Document medication administration and patient response. CASE FILE 04:
CASE NO. OO1 MEDICATION PROFILE DRUG STUDY ABELLO, FRITZIE GALE D. 3D1 CASE NO. OO1 MEDICATION PROFILE DRUG STUDY ABELLO, FRITZIE GALE D. 3D1